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2365-26-6

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2365-26-6 Structure

2365-26-6 Structure
IdentificationBack Directory
[Name]

1-formylisoquinoline thiosemicarbazone
[CAS]

2365-26-6
[Synonyms]

IQ-1
1-formylisoquinoline thiosemicarbazone
1-Isoquinolinecarbaldehyde thiosemicarbazone
Hydrazinecarbothioamide, 2-(1-isoquinolinylmethylene)-
[Molecular Formula]

C11H10N4S
[MDL Number]

MFCD01717568
[MOL File]

2365-26-6.mol
[Molecular Weight]

230.29
Chemical PropertiesBack Directory
[density ]

1.2608 (rough estimate)
[refractive index ]

1.5500 (estimate)
Hazard InformationBack Directory
[Uses]

IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription.
Safety DataBack Directory
[Toxicity]

LD50 intraperitoneal in mouse: 800mg/kg
2365-26-6 suppliers list
Company Name: Shaanxi Dideu Medichem Co. Ltd  
Telephone: 81148925 17391631969
Website:
Company Name: Shaanxi Dideu New Materials Co. Ltd  
Telephone: 18192503167
Website:
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