| Identification | Back Directory | [Name]
Methanone, 1-naphthalenyl[1-[3-(2-oxiranyl)propyl]-1H-indol-3-yl]- | [CAS]
2365471-31-2 | [Synonyms]
Methanone, 1-naphthalenyl[1-[3-(2-oxiranyl)propyl]-1H-indol-3-yl]- | [Molecular Formula]
C24H21NO2 | [MOL File]
2365471-31-2.mol | [Molecular Weight]
355.43 |
| Hazard Information | Back Directory | [Description]
JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).1 This cannabimimetic compound has frequently been found in herbal blends. 2,3,4 JWH 018 N-(4,5-epoxypentyl) analog is distinguished by a terminal epoxide group on the alkyl chain. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes. | [References]
1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Auw?rter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J. Mass Spectrom. 44(5),832-837(2009).
3. Lindigkeit, R., Boehme, A., Eiserloh, I., et al. Spice: A never ending story? Forensic Sci. Int. 191(1-3),58-63(2009).
4. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product Forensic Toxicol. 27,61-66(2009). |
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