| Chemical Properties | Back Directory | [Boiling point ]
454.9±27.0 °C(Predicted) | [density ]
0.975±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO:99.0(Max Conc. mg/mL);270.04(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.1(Max Conc. mM) | [form ]
Solid | [pka]
12.38±0.23(Predicted) | [color ]
White to off-white | [InChI]
1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24) | [InChIKey]
HSHXDCVZWHOWCS-UHFFFAOYSA-N | [SMILES]
[s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC |
| Hazard Information | Back Directory | [Uses]
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1]. | [Biological Activity]
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) th at effectively upregulates HDAC11 substrateserine hydroxymethyl transferase 2 (SHMT2)fatty acylation level in MCF7 cells (12.5 μM). | [IC 50]
HDAC11: 0.83 μM (IC50) | [References]
[1] Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. DOI:10.1021/acschembio.9b00292
[2] Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36(7):e22326. DOI:10.1096/fj.202101742RR |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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