| Identification | Back Directory | [Name]
5-Bromo-2-(2-fluoro-4-pyridinyl)-1,7-naphthyridin-8-amine | [CAS]
2375196-40-8 | [Synonyms]
5-Bromo-2-(2-fluoro-4-pyridinyl)-1,7-naphthyridin-8-amine | [Molecular Formula]
C13H8BrFN4 | [MOL File]
2375196-40-8.mol | [Molecular Weight]
319.13 |
| Chemical Properties | Back Directory | [Boiling point ]
484.6±40.0 °C(Predicted) | [density ]
1.669±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
3.08±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC50 of 0.93 μM, that plays important roles in neurological and psychiatric disorders[1][2]. | [References]
[1] Koc-Kan Ho, et al. Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73. DOI:10.1016/j.bmcl.2012.11.013
[2] Jon Read, et al. Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1962-1967. DOI:10.1016/j.bmcl.2019.05.032 |
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