| Chemical Properties | Back Directory | [Boiling point ]
597.1±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (218.10 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
15.06±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1]. | [storage]
Store at -20°C | [References]
[1] Jovanovi? M, et al. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. Eur J Med Chem. 2019 Aug 1;181:111580. DOI:10.1016/j.ejmech.2019.111580 |
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