| Identification | Back Directory | [Name]
6-Isoquinolinol, 7-methoxy-1-(3,4,5-trimethoxyphenyl)-, 6-(dihydrogen phosphate), sodium salt (1:2) | [CAS]
2376321-67-2 | [Synonyms]
IQTub4P
6-Isoquinolinol, 7-methoxy-1-(3,4,5-trimethoxyphenyl)-, 6-(dihydrogen phosphate), sodium salt (1:2) | [Molecular Formula]
C19H21NNaO8P | [MOL File]
2376321-67-2.mol | [Molecular Weight]
445.34 |
| Hazard Information | Back Directory | [Uses]
IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo[1]. | [in vivo]
IQTub4P (Balb/c mice, 25?mg/kg, IP and IV, once every two days, 3 administrations) is well-tolerated in vivo and can avoid short-term cumulative toxicity[1]. | Animal Model: | Balb/c mice (female)[1] | | Dosage: | 25?mg/kg | | Administration: | IP and IV, 3 administration, 48?h intervals | | Result: | Could avoid short-term cumulative toxicity, and was well-tolerated in vivo, with a single-administration maximal tolerated dose of 32?mg/kg (i.p.) and 50?mg/kg (i.v.). |
| [References]
[1] Kraus Y, Glas C, Melzer B, et al. Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors. Eur J Med Chem. 2020;186:111865. DOI:10.1016/j.ejmech.2019.111865 |
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