| Identification | Back Directory | [Name]
M2N12 | [CAS]
2376577-06-7 | [Synonyms]
M2N12
6-chloro-7-(((1-(4-methylbenzyl)-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-5,8-dione
CDK,M-2N12,M2N12,HBE,KB-VIN,A-549,Cyclin dependent kinase,MCF-7,cancer,Inhibitor,inhibit
5,8-Quinolinedione, 6-chloro-7-[[[1-[(4-methylphenyl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-
(R)-N2-(3-chloro-4-cyanophenyl)-N4-(3-(cyclopropylmethyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)morpholine-2,4-dicarboxamide | [Molecular Formula]
C20H16ClN5O2 | [MDL Number]
MFCD32263399 | [MOL File]
2376577-06-7.mol | [Molecular Weight]
393.83 |
| Chemical Properties | Back Directory | [Boiling point ]
615.3±65.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [solubility ]
DMF: 10 mg/ml
DMSO: 10 mg/ml | [form ]
Solid | [pka]
0.80±0.10(Predicted) | [color ]
Brown to red |
| Hazard Information | Back Directory | [Uses]
M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 ?μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of ?0.53? μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research[1]. | [References]
[1] Jing L, et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem. 2019 Sep 14;183:111696. DOI:10.1016/j.ejmech.2019.111696 |
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