| Identification | Back Directory | [Name]
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-[4-(difluoromethoxy)phenyl]-6-(2-methyl-2H-indazol-5-yl)-2-(2,2,2-trifluoroethoxy)- | [CAS]
2377493-28-0 | [Synonyms]
MAT2A-IN-3
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-[4-(difluoromethoxy)phenyl]-6-(2-methyl-2H-indazol-5-yl)-2-(2,2,2-trifluoroethoxy)- | [Molecular Formula]
C24H16F5N5O3 | [MOL File]
2377493-28-0.mol | [Molecular Weight]
517.41 |
| Hazard Information | Back Directory | [Uses]
MAT2A-IN-3 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-3 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-3 has the potential for the research of cancer diseases (extracted from patent WO2019191470A1, compound 265)[1]. | [References]
[1] Zenon D. Konteatis, et al. Heterobicyclic inhibitors of mat2a and methods of use for treating cancer. Patent WO2019191470A1. |
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