| Identification | Back Directory | [Name]
1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- | [CAS]
2378515-04-7 | [Synonyms]
1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- | [Molecular Formula]
C19H21ClN2O3S | [MOL File]
2378515-04-7.mol | [Molecular Weight]
392.9 |
| Hazard Information | Back Directory | [Uses]
E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models[1]. | [References]
[1] Mounier L, et al., Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation. J Med Chem. 2020 Nov 25;63(22):13680-13694. DOI:10.1021/acs.jmedchem.0c01201 |
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