| Identification | Back Directory | [Name]
1,2,4,5-Tetrazine, 3-[([1,1'-biphenyl]-4-ylmethyl)thio]-6-methyl- | [CAS]
2378619-75-9 | [Synonyms]
3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine
1,2,4,5-Tetrazine, 3-[([1,1'-biphenyl]-4-ylmethyl)thio]-6-methyl-
3-[({[1,1'-biphenyl]-4-yl}methyl)sulfanyl]-6-methyl-1,2,4,5-tetrazine
3-[({[1,1'-biphenyl]-4-yl}methyl)sulfanyl]-6-methyl-1,2,4,5-tetrazine (b-Tz) | [Molecular Formula]
C16H14N4S | [MOL File]
2378619-75-9.mol | [Molecular Weight]
294.37 |
| Hazard Information | Back Directory | [Uses]
3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine (b-Tz) is a minimal tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications. Tetrazines are often incorporated into chemical probes or other small-molecule tools using linkers that may impact physicochemical properties or the performance of the resulting conjugate product. Here, Lambert et al demonstrated the linker-free incorporation of b-Tz via silver-mediated Liebeskind-Srogl cross-coupling with a variety of aryl and heteroaryl boronic acids. This ″minimal″ tetrazine approach will facilitate the introduction of tetrazine into diverse complex molecules and improved probes for live-cell imaging and in vivo chemistry.
Supporting products
PdCl2(dppf): 697230
Ag2O: 226831 | [reaction suitability]
reaction type: click chemistry |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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