| Identification | Back Directory | [Name]
2′-Aminolupa-2,20(29)-dieno[3,2-d]thiazol-28-oic acid | [CAS]
2387902-92-1 | [Synonyms]
2′-Aminolupa-2,20(29)-dieno[3,2-d]thiazol-28-oic acid | [Molecular Formula]
C31H46N2O2S | [Molecular Weight]
510.78 |
| Chemical Properties | Back Directory | [Melting point ]
230 °C (decomp)(Solvent: Hexane) | [Boiling point ]
622.6±55.0 °C(Predicted) | [density ]
1.143±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
4.61±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization[1]. | [IC 50]
Caspase 3; Caspase-7; Bcl-2; Bax; PARP | [References]
[1] Borková L, et al. Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. Eur J Med Chem. 2020 Jan 1;185:111806. DOI:10.1016/j.ejmech.2019.111806 |
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