| Identification | Back Directory | [Name]
7-Propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine | [CAS]
2389988-31-0 | [Synonyms]
7-Propargyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl)guanine
7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
7-Propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine | [Molecular Formula]
C13H15N5O6 | [MDL Number]
MFCD34548957 | [MOL File]
2389988-31-0.mol | [Molecular Weight]
337.29 |
| Hazard Information | Back Directory | [Uses]
7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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