| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 2-[4-[[6-(hexahydro-1H-azepin-1-yl)hexyl]oxy]phenyl]-6-methyl- | [CAS]
2390042-05-2 | [Synonyms]
AChE-IN-14
4H-1-Benzopyran-4-one, 2-[4-[[6-(hexahydro-1H-azepin-1-yl)hexyl]oxy]phenyl]-6-methyl- | [Molecular Formula]
C28H35NO3 | [MOL File]
2390042-05-2.mol | [Molecular Weight]
433.58 |
| Hazard Information | Back Directory | [Uses]
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46?, 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki=?159.8?nM). AChE-IN-14 can be used for the research of Alzheimer’s disease[1]. | [IC 50]
AChE | [References]
[1] Marek Bajda, et al. Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands. Eur J Med Chem. 2020 Jan 1;185:111785. DOI:10.1016/j.ejmech.2019.111785 |
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