| Identification | Back Directory | [Name]
1,3-Dioxolo[4,5-g]isoquinolin-5(6H)-one, 9-chloro-6-[[1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl]methyl]-2-[trans-4-(dimethylamino)cyclohexyl]-7,8-dihydro-2,4-dimethyl-, (2R)- | [CAS]
2390367-27-6 | [Synonyms]
CPI-1328
1,3-Dioxolo[4,5-g]isoquinolin-5(6H)-one, 9-chloro-6-[[1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl]methyl]-2-[trans-4-(dimethylamino)cyclohexyl]-7,8-dihydro-2,4-dimethyl-, (2R)- | [Molecular Formula]
C28H36ClN3O4S | [MOL File]
2390367-27-6.mol | [Molecular Weight]
546.12 |
| Hazard Information | Back Directory | [Description]
CPI-1328 is a highly potent second-generation EZH2 inhibitor with extended residence times and improved biological activity. | [Uses]
CPI-1328 is an EZH2 inhibitor with a Ki value of 63 fM. | [IC 50]
EZH2 | [References]
[1] Stuckey JI, et al. Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity. J Biol Chem. 2021 Jan-Jun;296:100349. DOI:10.1016/j.jbc.2021.100349 |
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