| Identification | Back Directory | [Name]
5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene | [CAS]
239066-73-0 | [Synonyms]
AL438
AL-438
AL 438
5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene
1H-[1]Benzopyrano[3,4-f]quinoline, 2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-(2-propen-1-yl)- | [Molecular Formula]
C23H25NO2 | [MOL File]
239066-73-0.mol | [Molecular Weight]
347.45 |
| Hazard Information | Back Directory | [Description]
AL-438 is a non-steroidal selective modulator for the glucocorticoid receptor (GR). | [Uses]
AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2]. | [in vivo]
AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats[2]. | Animal Model: | Male Sprague Dawley rats (carrageenan paw edema model)[2] | | Dosage: | 1, 10, 100 mg/kg | | Administration: | P.o. | | Result: | Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay. |
| [References]
[1] Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. DOI:10.1016/j.mce.2006.11.006
[2] Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. DOI:10.1210/me.2002-0355 |
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