239088-22-3

1260529-12-1

239088-22-3

The general procedure for the synthesis of N-Fmoc-N-(2-oxoethyl)decylamine from the compound (CAS:1260529-12-1) was as follows: the pale yellow liquid 10 obtained from the above reaction was dissolved in dichloromethane (300 mL) and cooled to -10 °C. 37% hydrochloric acid (77 g, 0.75 mol) was slowly added dropwise under a tightly controlled temperature range (-10 to -20°C). After the dropwise addition, the reaction mixture was stirred at 10 °C (temperature range 10 to 30 °C) for 4 hours (time range 2 to 4 hours). Upon completion of the reaction, the reaction was neutralized by slow addition of 5% sodium bicarbonate solution (300 mL). The organic and aqueous layers were separated and the organic layer was dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the resulting residue was recrystallized from n-heptane to give a white solid product, 9H-fluorene-9-methyl decyl (2-oxoethyl) carbamate (20.3 g, 82.2% yield).