2395004-21-2

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2395004-21-2 Structure

Identification	Back Directory
[Name] BocNH-PEG11-CH2CH2N3
[CAS] 2395004-21-2
[Synonyms] N3-Peg11-NHBoc Boc-NH-PEG11-N3 BocNH-PEG11-CH2CH2N3 Azido-PEG11-Boc Amine
[Molecular Formula] C29H58N4O13
[MDL Number] MFCD31747091
[MOL File] 2395004-21-2.mol
[Molecular Weight] 670.8

Hazard Information	Back Directory
[Uses] Boc-NH-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG11-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
[IC 50] PEGs
[References] [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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