| Identification | Back Directory | [Name]
MBX-102/JNJ39659100 | [CAS]
23953-39-1 | [Synonyms]
MBX-102 acid
MBX-102/JNJ39659100
MBX-102 acid >=98% (HPLC), powder
(aR)-4-chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid
Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, (αR)- | [Molecular Formula]
C15H10ClF3O3 | [MDL Number]
MFCD19686974 | [MOL File]
23953-39-1.mol | [Molecular Weight]
330.686 |
| Chemical Properties | Back Directory | [Boiling point ]
404.8±45.0 °C(Predicted) | [density ]
1.428±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
2.46±0.10(Predicted) | [color ]
white to tan | [InChI]
1S/C15H10ClF3O3/c16-11-6-4-9(5-7-11)13(14(20)21)22-12-3-1-2-10(8-12)15(17,18)19/h1-8,13H,(H,20,21)/t13-/m1/s1 | [InChIKey]
DDTQLPXXNHLBAB-CYBMUJFWSA-N | [SMILES]
OC(=O)[C@H](Oc1cccc(c1)C(F)(F)F)c2ccc(Cl)cc2 |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
25-50/53 | [Safety Statements ]
45-60-61 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Uses]
MBX-102 acid is a selective partial PPAR-γ agonist. MBX-102 acid binds highly to plasma proteins, mainly serum albumin. MBX-102 acid can be used to study type 2 diabetes[1]. | [Biological Activity]
MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ. | [IC 50]
PPARγ | [References]
[1] Clarke HJ, et al. Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-gamma Agonist. PPAR Res. 2008;2008:465715. DOI:10.1155/2008/465715 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|