| Identification | Back Directory | [Name]
1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)- | [CAS]
2396639-11-3 | [Synonyms]
1H-Pyrrole-2-carboxylic acid, 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-(1-methylethyl)- | [Molecular Formula]
C24H20ClN3O2 | [MOL File]
2396639-11-3.mol | [Molecular Weight]
417.89 |
| Chemical Properties | Back Directory | [Boiling point ]
717.4±60.0 °C(Predicted) | [density ]
1.403±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.11±0.50(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1]. | [Biological Activity]
RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].
RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1].RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM[1].RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1].RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1]. | [References]
[1]. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793. |
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