| Identification | Back Directory | [Name]
MERANZIN | [CAS]
23971-42-8 | [Synonyms]
MERANZIN
Merancin
8-[[(S)-3,3-Dimethyloxiranyl]methyl]-7-methoxy-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 8-[[(2S)-3,3-dimethyl-2-oxiranyl]methyl]-7-methoxy- | [EINECS(EC#)]
200-158-5 | [Molecular Formula]
C15H16O4 | [MDL Number]
MFCD02683834 | [MOL File]
23971-42-8.mol | [Molecular Weight]
260.29 |
| Chemical Properties | Back Directory | [Melting point ]
89-92 °C(Solv: ethyl ether (60-29-7)) | [Boiling point ]
414.8±45.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [color ]
White to off-white | [Optical Rotation]
[α]/D -48.0 to -44.0° in chloroform (0.063 g/100 mL) | [InChI]
InChI=1S/C15H16O4/c1-15(2)12(19-15)8-10-11(17-3)6-4-9-5-7-13(16)18-14(9)10/h4-7,12H,8H2,1-3H3/t12-/m0/s1 | [InChIKey]
LSZONYLDFHGRDP-LBPRGKRZSA-N | [SMILES]
C1(=O)OC2=C(C[C@H]3C(C)(C)O3)C(OC)=CC=C2C=C1 | [LogP]
1.920 (est) |
| Hazard Information | Back Directory | [Uses]
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression[1][2]. | [target]
Immunology & Inflammation related | [References]
[1] Lan Li, et al. Chaihu-Shugan-San and Absorbed Meranzin Hydrate Induce Anti-Atherosclerosis and Behavioral Improvements in High-Fat Diet ApoE -/- Mice via Anti-Inflammatory and BDNF-TrkB Pathway. Biomed Pharmacother. 2019 Jul;115:108893. DOI:10.1016/j.biopha.2019.108893
[2] Rongwei Yan, et al. Preparative Isolation and Purification of Hainanmurpanin, Meranzin, and Phebalosin From Leaves of Murraya Exotica L. Using Supercritical Fluid Extraction Combined With Consecutive High-Speed Countercurrent Chromatography. J Sep Sci. 20 DOI:10.1002/jssc.201701423 |
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