| Hazard Information | Back Directory | [Uses]
KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC50s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF[1]. | [IC 50]
HDAC1: 12 nM (IC50); HDAC2: 68 nM (IC50) | [References]
[1] Yukihiro Itoh, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. J Med Chem. 2023 Oct 17. doi: 10.1021/acs.jmedchem.3c01095. Online ahead of print. DOI:10.1021/acs.jmedchem.3c01095 |
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