| Identification | Back Directory | [Name]
Acetamide, 2-[[3,4-dihydro-4-oxo-3-(2-phenylethyl)-2-pteridinyl]thio]-N-[4-(3-hydroxyphenyl)-2-thiazolyl]- | [CAS]
2397679-77-3 | [Synonyms]
PI3KC2α-IN-2
Acetamide, 2-[[3,4-dihydro-4-oxo-3-(2-phenylethyl)-2-pteridinyl]thio]-N-[4-(3-hydroxyphenyl)-2-thiazolyl]- | [Molecular Formula]
C25H20N6O3S2 | [MOL File]
2397679-77-3.mol | [Molecular Weight]
516.59 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
7.16±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
PITCOIN2 is a cell permeablepotentand highly selective inhibitor Phosphatidylinositol 3-kinase type 2α (PI3KC2α) catalytic activity. AlsoPITCOIN2 is a moderate inhibitor of PI3KC2β. PITCOIN2 inhibits PI3KC2α-mediated synthesis of PI(3,4)P2 and PI(3)P. It exhibits potent antithrombotic activity by counteracting platelet membrane remodeling. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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