| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[4-[(3-azidopropyl)amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- | [CAS]
2399455-71-9 | [Synonyms]
2,6-Piperidinedione, 3-[4-[(3-azidopropyl)amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- | [Molecular Formula]
C16H18N6O3 | [MOL File]
2399455-71-9.mol | [Molecular Weight]
342.36 |
| Hazard Information | Back Directory | [Description]
BUN55719 is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC3 linker with terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has no formal name. | [Uses]
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups[1]. | [storage]
Store at -20°C | [References]
[1] Liu H, et al. Construction of an IMiD-based azide library as a kit for PROTAC research. Org Biomol Chem. 2021 Jan 6;19(1):166-170. DOI:10.1039/d0ob02120b |
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