| Identification | Back Directory | [Name]
1-Piperazinecarboxylic acid, 4-[3-(3-methylphenyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-, ethyl ester | [CAS]
2402735-14-0 | [Synonyms]
DPP-4 inhibitor 3
1-Piperazinecarboxylic acid, 4-[3-(3-methylphenyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-, ethyl ester | [Molecular Formula]
C19H22N6O2 | [MOL File]
2402735-14-0.mol | [Molecular Weight]
366.42 |
| Hazard Information | Back Directory | [Uses]
DPP-4-IN-3 (Compound 5a) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 0.75 nM. DPP-4-IN-3 shows excellent antioxidant and insulinotropic activity[1]. | [IC 50]
DPP-4 | [References]
[1] Bindu B, et al. Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities. Eur J Med Chem. 2020 Feb 1;187:111912. DOI:10.1016/j.ejmech.2019.111912 |
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