| Identification | Back Directory | [Name]
5H-[1]Benzothieno[3,2-d]thiazolo[3,2-a]pyrimidin-3(2H)-one, 9-chloro-5-(2-naphthalenyl)- | [CAS]
2402779-21-7 | [Synonyms]
Sirt1/2-IN-1
5H-[1]Benzothieno[3,2-d]thiazolo[3,2-a]pyrimidin-3(2H)-one, 9-chloro-5-(2-naphthalenyl)- | [Molecular Formula]
C22H13ClN2OS2 | [MOL File]
2402779-21-7.mol | [Molecular Weight]
420.93 |
| Hazard Information | Back Directory | [Uses]
Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 μg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 μg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1]. | [IC 50]
SIRT1: 1.81 μg/mL (IC50); SIRT2: 2.10 μg/mL (IC50); SIRT3: 20.5 μg/mL (IC50) | [References]
[1] Khalil NA, et al. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. Eur J Med Chem. 2020 Feb 1;187:111926. DOI:10.1016/j.ejmech.2019.111926 |
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