| Identification | Back Directory | [Name]
2-Propenamide, N-[2-[[2-[6-(difluoromethyl)-1H-indazol-3-yl]-1H-indol-4-yl]oxy]ethyl]- | [CAS]
2404603-41-2 | [Synonyms]
ITK inhibitor 5
2-Propenamide, N-[2-[[2-[6-(difluoromethyl)-1H-indazol-3-yl]-1H-indol-4-yl]oxy]ethyl]- | [Molecular Formula]
C21H18F2N4O2 | [MOL File]
2404603-41-2.mol | [Molecular Weight]
396.39 |
| Hazard Information | Back Directory | [Uses]
ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC50s of 5.6, 25 nM for ITK, BTK, respectively[1]. | [References]
[1] Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918. DOI:10.1016/j.ejmech.2019.111918 |
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