| Identification | Back Directory | [Name]
2-Propenamide, N-[2-[[2-[6-(difluoromethyl)-1H-indazol-3-yl]-6-(phenylmethyl)-1H-indol-4-yl]oxy]ethyl]- | [CAS]
2404604-06-2 | [Synonyms]
ITK inhibitor 6
2-Propenamide, N-[2-[[2-[6-(difluoromethyl)-1H-indazol-3-yl]-6-(phenylmethyl)-1H-indol-4-yl]oxy]ethyl]- | [Molecular Formula]
C28H24F2N4O2 | [MOL File]
2404604-06-2.mol | [Molecular Weight]
486.51 |
| Hazard Information | Back Directory | [Uses]
ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1]. | [References]
[1] Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918. DOI:10.1016/j.ejmech.2019.111918 |
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