| Identification | Back Directory | [Name]
1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)- | [CAS]
2404756-81-4 | [Synonyms]
X5050
XX5050
1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)- | [Molecular Formula]
C17H15N3O3 | [MOL File]
2404756-81-4.mol | [Molecular Weight]
309.32 |
| Hazard Information | Back Directory | [Uses]
X5050 is a REST inhibitor, with an EC50 of 2.1 μM[1]. | [in vivo]
X5050 (2 x 2μl of 20 mM) is active in HD pathological context[1]. | Animal Model: | 12-week-old male C57Bl6 mice[1].2 | | Dosage: | 2 x 2μl of 20 mM in 10% DMSO in water. | | Administration: | Intraventricular injection. | | Result: | Increased BDNF expression.
A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum.
Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.
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| [References]
[1] Jérémie Charbord, et al. High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells. 2013 Sep;31(9):1816-28. DOI:10.1002/stem.1430 |
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ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878 |
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https://www.chemicalbook.com/ShowSupplierProductsList15061/0.htm |
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