| Identification | Back Directory | [Name]
OM-1700 | [CAS]
2406276-78-4 | [Synonyms]
OM-1700
2-Pyridinecarboxamide, N-[trans-3-[5-(5-ethoxy-2-pyridinyl)-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]cyclobutyl]- | [Molecular Formula]
C25H23FN6O2 | [MOL File]
2406276-78-4.mol | [Molecular Weight]
458.49 |
| Hazard Information | Back Directory | [Uses]
OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM)[1]. | [IC 50]
TNKS1: 127 nM (IC50); TNKS2: 14 nM (IC50) | [References]
[1] Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949. DOI:10.1021/acs.jmedchem.1c01264 |
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