| Identification | Back Directory | [Name]
Butanedioic acid, 2-[(4-fluorophenyl)methylene]-3-(phenylmethyl)- | [CAS]
2407652-42-8 | [Synonyms]
Butanedioic acid, 2-[(4-fluorophenyl)methylene]-3-(phenylmethyl)- | [Molecular Formula]
C18H15FO4 | [MOL File]
2407652-42-8.mol | [Molecular Weight]
314.31 |
| Chemical Properties | Back Directory | [Boiling point ]
508.3±50.0 °C(Predicted) | [density ]
1.341±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
3.78±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit immune-responsive gene 1 (IRG1) activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases[1]. | [in vivo]
IRG1-IN-1 (compound 6) (i.p.; 0.2 mg/kg; 27 days) shows antitumor effect in C57BL/6 mice[1]. | Animal Model: | C57BL/6 mice[1] | | Dosage: | 0.2 mg/kg | | Administration: | IP; 27 days | | Result: | Increased survival of C57BL/6 mice bearing mouse CT26 colorectal tumors.
Decreased intratumoral frequency of M-MDSCs in tumors.
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| [References]
[1] Adonia Papathanassiu, et al. Compositions and methods of using itaconic acid derivatives. Patent. US20210261495A1. |
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