| Identification | Back Directory | [Name]
1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)- | [CAS]
240797-64-2 | [Synonyms]
Tyrosinase-IN-11
1,3-Bis(2,4-dihydroxyphenyl)propan-1-one
1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)- | [Molecular Formula]
C15H14O5 | [MOL File]
240797-64-2.mol | [Molecular Weight]
274.27 |
| Chemical Properties | Back Directory | [Melting point ]
228-229 °C | [Boiling point ]
578.3±35.0 °C(Predicted) | [density ]
1.429±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.70±0.35(Predicted) | [color ]
Pink to orange |
| Hazard Information | Back Directory | [Uses]
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1]. | [in vivo]
Tyrosinase-IN-11 (compound 11c; 0.5, 1 mM; topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks) exhibits powerful antimelanogenesis ability in a guinea pig model in vivo[1].
| Animal Model: | Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp[1] | | Dosage: | 0.5, 1 mM | | Administration: | Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks | | Result: | Inhibited the production of melanin in a dose-dependent manner.
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| [References]
[1] Songtao Xue, et al. Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation. J Med Chem. 2023 Apr 13;66(7):5099-5117. DOI:10.1021/acs.jmedchem.3c00012 |
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