| Identification | Back Directory | [Name]
Benzamide, N-hydroxy-4-[[(3R)-3-(1H-indol-3-ylmethyl)-2,5-dioxo-1-piperazinyl]methyl]- | [CAS]
2408286-73-5 | [Synonyms]
HDAC6-IN-10
Benzamide, N-hydroxy-4-[[(3R)-3-(1H-indol-3-ylmethyl)-2,5-dioxo-1-piperazinyl]methyl]- | [Molecular Formula]
C21H20N4O4 | [MOL File]
2408286-73-5.mol | [Molecular Weight]
392.41 |
| Hazard Information | Back Directory | [Uses]
HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells[1]. | [IC 50]
HDAC6: 0.73 nM (IC50); HDAC10: 105 nM (IC50); HDAC8: 513 nM (IC50); HDAC7: 752 nM (IC50); HDAC11: 1800 nM (IC50); HDAC9: 2560 nM (IC50); HDAC5: 4370 nM (IC50); HDAC4: 5620 nM (IC50); HDAC1: 8020 nM (IC50) | [References]
[1] Xin Chen, et al. Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity. Eur J Med Chem. 2020 Feb 1;187:111950. DOI:10.1016/j.ejmech.2019.111950 |
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