| Identification | Back Directory | [Name]
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- | [CAS]
2408639-81-4 | [Synonyms]
Topoisomerase I inhibitor 7
1H-Naphth[2,3-f]indole-5,10-dione, 3-[[(3S)-3-amino-1-pyrrolidinyl]carbonyl]-4,11-dihydroxy-2-methyl- | [Molecular Formula]
C22H19N3O5 | [MOL File]
2408639-81-4.mol | [Molecular Weight]
405.4 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones[1]. | [References]
[1] Tikhomirov AS, et al. Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties. Eur J Med Chem. 2020 Aug 1;199:112294. DOI:10.1016/j.ejmech.2020.112294 |
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