| Identification | Back Directory | [Name]
2-Butenoic acid, 3-methyl-, (1R,2R,5S,11R)-1,5-dimethyl-8-methylene-5-(4-methyl-3-penten-1-yl)-7-oxo-12-oxabicyclo[9.1.0]dodec-3-en-2-yl ester | [CAS]
2408643-60-5 | [Synonyms]
HSP90-IN-12
2-Butenoic acid, 3-methyl-, (1R,2R,5S,11R)-1,5-dimethyl-8-methylene-5-(4-methyl-3-penten-1-yl)-7-oxo-12-oxabicyclo[9.1.0]dodec-3-en-2-yl ester | [Molecular Formula]
C25H36O4 | [MOL File]
2408643-60-5.mol | [Molecular Weight]
400.55 |
| Hazard Information | Back Directory | [Uses]
Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro. | [References]
[1] Miura K,et al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253. DOI:10.1016/j.bmc.2019.115253 |
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