| Identification | Back Directory | [Name]
2-Propenamide, N-hydroxy-3-[6-(4-methoxyphenoxy)-2-quinolinyl]-, (2E)- | [CAS]
2409072-27-9 | [Synonyms]
HDAC6-IN-11
2-Propenamide, N-hydroxy-3-[6-(4-methoxyphenoxy)-2-quinolinyl]-, (2E)- | [Molecular Formula]
C19H16N2O4 | [MOL File]
2409072-27-9.mol | [Molecular Weight]
336.34 |
| Hazard Information | Back Directory | [Uses]
HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1]. | [IC 50]
HDAC6: 20.7 nM (IC50); HDAC8: 7750 nM (IC50) | [References]
[1] Shih-Wei Wang, et al. Synthesis and biological evaluation of 2-quinolineacrylamides. Bioorg Med Chem. 2020 Feb 1;28(3):115250. DOI:10.1016/j.bmc.2019.115250 |
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