| Identification | Back Directory | [Name]
2-Buten-1-amine, 3-fluoro-4-(phenylsulfonyl)-, (2Z)- | [CAS]
2409963-50-2 | [Synonyms]
PXS-4787
2-Buten-1-amine, 3-fluoro-4-(phenylsulfonyl)-, (2Z)- | [Molecular Formula]
C10H12FNO2S | [MOL File]
2409963-50-2.mol | [Molecular Weight]
229.27 |
| Hazard Information | Back Directory | [Uses]
PXS-4787 is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively[1]. | [in vivo]
PXS-4787 (3%, oil in water cream; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application[1].
PXS-4787 (3%, oil in water cream; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application[1].
| Animal Model: | Porcine excision injury model (female Juvenile pigs, 18-20 kg)[1] | | Dosage: | 3%, oil in water cream; 400 mg cream applied to 16 cm2 | | Administration: | External application; 1, 2 and 3 weeks post-injury; once dailly, for 12 weeks | | Result: | Improved the appearance of scar in relevant in vivo models, indicative of a targetdriven, as opposed to compound-specific, effect. |
| [References]
[1] Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. DOI:10.1038/s41467-022-33148-5 |
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| Company Name: |
Twochem Co.Ltd
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| Tel: |
021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
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