| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-[[2-[[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]thio]-4-pyrimidinyl]amino]- | [CAS]
2411059-71-5 | [Synonyms]
Carbonic anhydrase inhibitor 11
Benzenesulfonamide, 4-[[2-[[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]thio]-4-pyrimidinyl]amino]- | [Molecular Formula]
C19H15F3N4O3S2 | [MOL File]
2411059-71-5.mol | [Molecular Weight]
468.47 |
| Hazard Information | Back Directory | [Uses]
Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows Ki values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively[1]. | [References]
[1] Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. Eur J Med Chem. 2022;228:114004. DOI:10.1016/j.ejmech.2021.114004 |
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