| Chemical Properties | Back Directory | [Boiling point ]
1004.8±65.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.73±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity[1]. | [IC 50]
Cereblon |
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