| Identification | Back Directory | [Name]
Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-ylmethyl ester | [CAS]
241127-79-7 | [Synonyms]
NSC689857
NSC-689857
NSC 689857
Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-ylmethyl ester | [Molecular Formula]
C25H29NO4 | [MOL File]
241127-79-7.mol | [Molecular Weight]
407.5 |
| Hazard Information | Back Directory | [Description]
NSC-689857 is an inhibitor of the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro. | [Uses]
NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others[1][2]. | [References]
[1] Vuong W, et al. High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer. J Pharmacol Exp Ther. 2016 Nov;359(2):256-261. DOI:10.1124/jpet.116.234567
[2] Lough L, et al. Chemical probes of Skp2-mediated p27 ubiquitylation and degradation. Medchemcomm. 2018 Jun 11;9(7):1093-1104. DOI:10.1039/c8md00140e |
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