| Identification | Back Directory | [Name]
Propanamide, N-[6-[3,4-dihydro-3-[2-(4-morpholinyl)ethyl]-4-oxo-6-quinazolinyl]-1H-benzimidazol-2-yl]- | [CAS]
2412144-74-0 | [Synonyms]
Aurora A inhibitor 2
Propanamide, N-[6-[3,4-dihydro-3-[2-(4-morpholinyl)ethyl]-4-oxo-6-quinazolinyl]-1H-benzimidazol-2-yl]- | [Molecular Formula]
C24H26N6O3 | [MOL File]
2412144-74-0.mol | [Molecular Weight]
446.5 |
| Hazard Information | Back Directory | [Uses]
Aurora A inhibitor 2 (Compound 16h) is a potent Aurora A kinase inhibitor with an IC50 of 21.94 nM. Aurora A inhibitor 2 induces caspase-dependent apoptosis in MDA-MB-231 cells[1]. | [IC 50]
Aurora A: 21.94 nM (IC50); Aurora B: 273.18 nM (IC50) | [References]
[1] Chengcheng Fan, et al. Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition. Eur J Med Chem. 2020 Mar 15;190:112108. DOI:10.1016/j.ejmech.2020.112108 |
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