| Identification | Back Directory | [Name]
LEUPEPTIN HYDROCHLORIDE | [CAS]
24125-16-4 | [Synonyms]
LEUPEPTIN HYDROCHLORIDE
ACETYL-LEU-LEU-ARG-AL HCL
Leupeptin hydrochloride >90%
ACETYL-LEU-LEU-ARG-AL HYDROCHLORIDE
LEUPEPTIN HYDROCHLORIDE, HIGH PURITY
leupeptin hydrochloride from*microbial source
N2-[N-(N-Acetyl-L-leucyl)-L-leucyl]-DL-argininal monohydrochloride
L-Leucinamide, N-acetyl-L-leucyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, monohydrochloride
N-Acetyl-L-Leucyl-N-[4-[(Aminoiminomethyl)Amino]-1-Formylbutyl]-L-Leucinamide Monohydrochloride
(S)-2-acetaMido-N-((S)-1-(((S)-5-guanidino-1-oxopentan-2-yl)aMino)-4-Methyl-1-oxopentan-2-yl)-4-MethylpentanaMide hydrochloride | [Molecular Formula]
C20H39ClN6O4 | [MDL Number]
MFCD00133457 | [MOL File]
24125-16-4.mol | [Molecular Weight]
463.01 |
| Chemical Properties | Back Directory | [Appearance]
solid | [storage temp. ]
−20°C
| [form ]
powder | [Stability:]
Stable, but store cold. Incompatible with strong bases, strong acids. | [biological source]
microbial | [Water Solubility ]
water: 50mg/mL, clear, colorless to yellow |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Uses]
Leupeptin Hydrochloride is a protease inhibitor, used in the characterization of macroautophagic flux in vivo using leupeptin-based assay. | [Biochem/physiol Actions]
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.) |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|