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2412937-65-4

2412937-65-4 Structure

2412937-65-4 Structure
IdentificationBack Directory
[Name]

TLR8 agonist 2 hydrochloride
[CAS]

2412937-65-4
[Synonyms]

TLR8 agonist 2 hydrochloride
Hazard InformationBack Directory
[Uses]

TLR8 agonist 2 hydrochloride is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 hydrochloride shows less active against human TLR7 (EC50 of 33.33 μM)[1].
[in vivo]

The pharmacokinetic related parameters of TLR8 agonist 2 (Example 1) in mice administered with the intravenous administration of 1 mg/kg and the oral administration of 5 mg/kg are detected. The T1/2 of TLR8 agonist 2 are 0.25 h (1 mg/kg i.v.) and 0.5 h (5 mg/kg p.o.), the AUClast are 450 ng/mL*hr (i.v.) and 624 ng/mL*hr (p.o.). And for oral administration, the bioavailability (%F) is 27.7%[1]

[IC 50]

TLR8: 3 nM (EC50); TLR7: 33.33 μM (EC50)
[References]

[1] Zhe Cai, et al. Tlr8 agonist. WO2020057604A1.
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