| Identification | Back Directory | [Name]
2-Propenamide, N-[2-methyl-5-[[6-(3-quinolinyl)-4-quinazolinyl]amino]phenyl]- | [CAS]
2413257-51-7 | [Synonyms]
PI3Kδ-IN-11
2-Propenamide, N-[2-methyl-5-[[6-(3-quinolinyl)-4-quinazolinyl]amino]phenyl]- | [Molecular Formula]
C27H21N5O | [MOL File]
2413257-51-7.mol | [Molecular Weight]
431.49 |
| Hazard Information | Back Directory | [Uses]
PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies[1]. | [IC 50]
PI3Kδ: 27.5 nM (IC50) | [References]
[1] Teng Y, Li X, Ren S, et al. Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity. Eur J Med Chem. 2020;208:112865. DOI:10.1016/j.ejmech.2020.112865 |
|
|