| Identification | Back Directory | [Name]
2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] | [CAS]
2413565-19-0 | [Synonyms]
COX-2-IN-26
2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] | [Molecular Formula]
C23H21N7OS3 | [MOL File]
2413565-19-0.mol | [Molecular Weight]
507.65 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 μM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1]. | [in vivo]
COX-2-IN-26 (28 μM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 102% and 119% in 4h and 3h, respectively[1].
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COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats[1]. | [IC 50]
COX-2: 0.067 μM (IC50); COX-1: 10.61 μM (IC50); 15-LOX: 1.96 μM (IC50) | [References]
[1] Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403. DOI:10.1016/j.bmc.2020.115403 |
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