| Identification | Back Directory | [Name]
2-Thiazolamine, N-[1,1'-biphenyl]-4-yl-4-imidazo[1,2-a]pyrimidin-3-yl- | [CAS]
2413648-96-9 | [Synonyms]
EV-A71-IN-1
2-Thiazolamine, N-[1,1'-biphenyl]-4-yl-4-imidazo[1,2-a]pyrimidin-3-yl- | [Molecular Formula]
C21H15N5S | [MOL File]
2413648-96-9.mol | [Molecular Weight]
369.44 |
| Hazard Information | Back Directory | [Uses]
EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC50 of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC50>56.2 μM)[1]. | [References]
[1] Xu Z, et al. Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors. Bioorg Chem. 2022;122:105683. DOI:10.1016/j.bioorg.2022.105683 |
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