| Identification | Back Directory | [Name]
Acetamide, N-[4-[(2-pyridinylamino)sulfonyl]phenyl]-2-([1,2,4]triazolo[4,3-a]quinoxalin-4-ylthio)- | [CAS]
2413901-61-6 | [Synonyms]
Topoisomerase II inhibitor 9
Acetamide, N-[4-[(2-pyridinylamino)sulfonyl]phenyl]-2-([1,2,4]triazolo[4,3-a]quinoxalin-4-ylthio)- | [Molecular Formula]
C22H17N7O3S2 | [MOL File]
2413901-61-6.mol | [Molecular Weight]
491.55 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1]. | [IC 50]
Topoisomerase II: 0.97 μM (IC50) | [References]
[1] Eissa IH, et al. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors. Arch Pharm (Weinheim). 2019 Nov;352(11):e1900123. DOI:10.1002/ardp.201900123 |
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