| Identification | Back Directory | [Name]
2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- | [CAS]
2413940-56-2 | [Synonyms]
NF-κB/MAPK-IN-1 2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- | [Molecular Formula]
C27H27NO7 | [MOL File]
2413940-56-2.mol | [Molecular Weight]
477.51 |
| Chemical Properties | Back Directory | [Boiling point ]
677.4±55.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.23±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 μM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1]. | [IC 50]
NF-κB; p38; COX-2 | [References]
[1] Hu YS, et al. Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Bioorg Chem. 2020 May;98:103735. DOI:10.1016/j.bioorg.2020.103735 |
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