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2413940-56-2

2413940-56-2 Structure

2413940-56-2 Structure
IdentificationBack Directory
[Name]

2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-
[CAS]

2413940-56-2
[Synonyms]

NF-κB/MAPK-IN-1
2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-
[Molecular Formula]

C27H27NO7
[MOL File]

2413940-56-2.mol
[Molecular Weight]

477.51
Chemical PropertiesBack Directory
[Boiling point ]

677.4±55.0 °C(Predicted)
[density ]

1.225±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

12.23±0.70(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 μM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].
[IC 50]

NF-κB; p38; COX-2
[References]

[1] Hu YS, et al. Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Bioorg Chem. 2020 May;98:103735. DOI:10.1016/j.bioorg.2020.103735
Spectrum DetailBack Directory
[Spectrum Detail]

2-Propenamide, N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-(2413940-56-2)1HNMR
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