| Identification | Back Directory | [Name]
Thiourea, N-(4-fluorophenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- | [CAS]
2413974-53-3 | [Synonyms]
Mt KARI-IN-4
Thiourea, N-(4-fluorophenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- | [Molecular Formula]
C13H8FN5O3S2 | [MOL File]
2413974-53-3.mol | [Molecular Weight]
365.36 |
| Hazard Information | Back Directory | [Uses]
Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL)[1]. | [References]
[1] Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178. DOI:10.1016/j.ejmech.2020.112178 |
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