| Identification | Back Directory | [Name]
Acetamide, 2-[[5-[2-(3-chlorophenyl)-4-oxo-3-thiazolidinyl]-1,3,4-thiadiazol-2-yl]thio]-N-[4-(methylsulfonyl)phenyl]- | [CAS]
2414099-82-2 | [Synonyms]
HIV-1 inhibitor-39
Acetamide, 2-[[5-[2-(3-chlorophenyl)-4-oxo-3-thiazolidinyl]-1,3,4-thiadiazol-2-yl]thio]-N-[4-(methylsulfonyl)phenyl]- | [Molecular Formula]
C20H17ClN4O4S4 | [MOL File]
2414099-82-2.mol | [Molecular Weight]
541.09 |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-39 (compound 3c) is a potent HIV-1 inhibitor with an EC50 of >112.88 μM. HIV-1 inhibitor-39 shows anti-RT (HIV-1 reverse transcriptase) activities with an IC50 of 15.75 μM. HIV-1 inhibitor-39 shows cytotoxicity for MT-4 cells with an CC50 of 112.9 μM[1]. | [IC 50]
HIV-1: >112.88 μM (EC50) | [References]
[1] Buemi MR, et al. Inhibition of HIV-1 RT activity by a new series of 3-(1,3,4-thiadiazol-2-yl)thiazolidin-4-one derivatives. Bioorg Med Chem. 2020 Apr 15;28(8):115431. DOI:10.1016/j.bmc.2020.115431 |
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