| Identification | Back Directory | [Name]
Cyclopropaneacetamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-α-hydroxy-, (αR)- | [CAS]
2414254-37-6 | [Synonyms]
Cyclopropaneacetamide, N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-α-hydroxy-, (αR)- | [Molecular Formula]
C29H28FN3O6 | [MOL File]
2414254-37-6.mol | [Molecular Weight]
533.55 |
| Chemical Properties | Back Directory | [Boiling point ]
965.7±65.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.18±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent. (αR)-Cyclopropaneacetamide-Exatecan inhibits U87MG and SK-BR-3 cells proliferation, with IC50s of 8.11 and 2.31 μM[1]. | [IC 50]
Camptothecins | [References]
[1] Haiqing H, et, al. Antibody-drug conjugate and medical use thereof. WO2021190564A1. |
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